Wound Hygiene TM is a simple, early intervention strategy that was developed to address the problem of biofilm in hard-to-heal wounds. Wound Hygiene TM and AQUACEL ® Ag+ dressings: an early intervention against biofilm Results indicated that 78% of wounds progressed following treatment with AQUACEL ® Ag+, while 13% healed during the average evaluation period of 3.9 weeks. The ability of AQUACEL ® Ag+ dressings to promote healing in chronic wounds that were stalled or deteriorating at baseline was evaluated in a study of 111 patients from 60 centres across the UK and Ireland (Metcalf et al, 2017). A body of evidence with 25 publications exists that demonstrate the efficacy of AQUACEL ® Ag+ dressings and biofilm, in vitro, in vivo and in clinical practice.Īn in vitro study (Bowler and Parsons, 2016) found that MORE THAN SILVER TM technology was able to effectively disrupt biofilm and kill bacteria, presenting a new therapeutic option for the management of hard-to-heal wounds. MORE THAN SILVER TM technology was developed following years of research in which more than 60,000 potential agents were combined and tested, before the combination of surfactant, metal chelating agent and ionic silver were discovered. What is the evidence for using the AQUACEL ® Ag+ dressings range? EDTA helps to remove the metal ions that hold the biofilm’s protective matrix together, exposing the micro-organisms within the biofilm to the anti-microbial effects of ionic silver (Chen and Stewart, 2000 Banin et al, 2006 Said et al, 2014). Metal chelating agents such as EDTA strongly bind and attract metal ions, boosting the action of surfactants. BEC, the surfactant component of AQUACEL ® Ag+ dressings, reduces biofilm surface tension, making it more susceptible to the actions of the metal chelating agent EDTA, and ionic silver (Chen and Stewart, 2000 Banin et al, 2006 Said et al, 2014 Seth et al, 2014). Surfactant reduces surface tension, aiding the removal of contaminants from surfaces. This combination has been shown to be more effective when compared to ionic silver alone (Bowler and Parsons, 2016). These components are specifically formulated to act synergistically to disrupt and destroy biofilm and prevent its reformation. Mode of action: how does AQUACEL ®Ag+ disrupt and destroy biofilm?ĪQUACEL ® Ag+ dressings use Hydrofiber ® technology to create a moist wound healing interface, in conjunction with MORE THAN SILVER TM technology that combines three components – a surfactant, a metal chelating agent and ionic silver.
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